This comprehensive, state-of-the-art handbook synthesizes the full breadth of contemporary knowledge about depression. Bringing together leading depression researchers and clinical practitioners, the volume offers in-depth coverage of the epidemiology, course, and outcome of depressive disorders; current issues in classification, assessment, and diagnosis; vulnerability and risk factors; models of depression, including psychological and biological perspectives; and effective approaches to prevention and treatment. Described are current approaches to pharmacotherapy; advances in cognitive-behavioral, interpersonal, couple, and family treatments; and innovations in understanding and treating child and adolescent depression. Also addressed are culture and gender differences; depression in later life; and assessment and management of suicidality.